Modeling the Pulse Profiles of Millisecond Pulsars in the Second LAT Catalog of gamma-ray Pulsars

Significant gamma-ray pulsations have been detected from ~40 millisecond pulsars (MSPs) using 3 years of sky-survey data from the Fermi LAT and radio timing solutions from across the globe. We have fit the radio and gamma-ray pulse profiles of these MSPs using geometric versions of slot gap and outer gap gamma-ray emission models and radio cone and core models. For MSPs with radio and gamma-ray peaks aligned in phase we also explore low-altitude slot gap gamma-ray models and caustic radio models. The best-fit parameters provide constraints on the viewing geometries and emission sites. While the exact pulsar magnetospheric geometry is unknown, we can use the increased number of known gamma-ray MSPs to look for significant trends in the population which average over these uncertainties.Comment: 4 pages, 2 figures, to appear in the proceedings of the 5th International Symposium on High-Energy Astronom

Contribution to Cherenkov Resolution from Knock-on Electrons

Calculations of the mean and standard error of the added Cerenkov component from knock-on electrons for sample counters with refractive indices ranging from n = 1.03 to n = 1.49 are presented. We find that this contribution to the Cerenkov resolution is significant, but not dominant, for typical detector parameters

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor

L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood. The physiological effects of glutamate are mediated through two functionally distinct receptor families. While activation of metabotropic (G-protein coupled) glutamate receptors results in modulation of neuronal excitability and transmission, the ionotropic glutamate receptors (ligand-gated ion channels) are responsible for mediating the fast synaptic response to extracellular glutamate

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization.

Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI). HCV tropism is restricted to the liver, where hepatocytes are tightly packed. Here, we demonstrate that SR-BI and CLDN1 expression is modulated in confluent human hepatoma cells, with both receptors being enriched at cell-cell junctions. Cellular contact increased HCV pseudoparticle (HCVpp) and HCV particle (HCVcc) infection and accelerated the internalization of cell-bound HCVcc, suggesting that the cell contact modulation of receptor levels may facilitate the assembly of receptor complexes required for virus internalization. CLDN1 overexpression in subconfluent cells was unable to recapitulate this effect, whereas increased SR-BI expression enhanced HCVpp entry and HCVcc internalization, demonstrating a rate-limiting role for SR-BI in HCV internalization

The mission oriented terminal area simulation facility

The Mission Oriented Terminal Area Simulation (MOTAS) was developed to provide an ATC environment in which flight management and flight operations research studies can be conducted with a high degree of realism. This facility provides a flexible and comprehensive simulation of the airborne, ground-based and communication aspects of the airport terminal area environment. Major elements of the simulation are: an airport terminal area environment model, two air traffic controller stations, several aircraft models and simulator cockpits, four pseudo pilot stations, and a realistic air-ground communications network. MOTAS has been used for one study with the DC-9 simulator and a series of data link studies are planned in the near future

Domain wall dynamics in expanding spaces

We study the effects on the dynamics of kinks due to expansions and contractions of the space. We show that the propagation velocity of the kink can be adiabatically tuned through slow expansions/contractions, while its width is given as a function of the velocity. We also analyze the case of fast expansions/contractions, where we are no longer on the adiabatic regime. In this case the kink moves more slowly after an expansion-contraction cycle as a consequence of loss of energy through radiation. All these effects are numerically studied in the nonlinear Klein-Gordon equations (both for the sine-Gordon and for the phi^4 potential), and they are also studied within the framework of the collective coordinate evolution equations for the width and the center of mass of the kink. These collective coordinate evolution equations are obtained with a procedure that allows us to consider even the case of large expansions/contractions.Comment: LaTeX, 18 pages, 2 figures, improved version to appear in Phys Rev